John F Engelhardt Selected Research

NF-kappa B (NF-kB)

5/2008	Endosomal NADPH oxidase regulates c-Src activation following hypoxia/reoxygenation injury.
1/2007	Pleiotropic functions of TNF-alpha determine distinct IKKbeta-dependent hepatocellular fates in response to LPS.
3/2004	IkappaBalpha and IkappaBbeta possess injury context-specific functions that uniquely influence hepatic NF-kappaB induction and inflammation.
3/2003	Genetic redox preconditioning differentially modulates AP-1 and NF kappa B responses following cardiac ischemia/reperfusion injury and protects against necrosis and apoptosis.
1/2003	Tyrosine phosphorylation of I kappa B alpha activates NF kappa B through a redox-regulated and c-Src-dependent mechanism following hypoxia/reoxygenation.

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John F Engelhardt Research Topics

Disease

35	Cystic Fibrosis (Mucoviscidosis) 11/2023 - 01/2002
17	Infections 01/2018 - 03/2002
10	Lung Diseases (Lung Disease) 04/2024 - 12/2004
6	Neoplasms (Cancer) 01/2018 - 04/2002
6	Hypoxia (Hypoxemia) 07/2013 - 12/2002
5	Inflammation (Inflammations) 11/2023 - 03/2004
4	Fibrosis (Cirrhosis) 11/2023 - 02/2010
4	Bacterial Infections (Bacterial Infection) 01/2019 - 11/2003
4	Ischemia 07/2013 - 03/2003
4	Wounds and Injuries (Trauma) 06/2009 - 12/2002
3	Hyperglycemia 08/2021 - 01/2016
3	Respiratory Tract Infections (Respiratory Tract Infection) 01/2020 - 10/2015
3	Disease Progression 11/2016 - 07/2009
3	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 11/2011 - 02/2008
3	Hypertension (High Blood Pressure) 07/2007 - 11/2003
2	Meconium Ileus 04/2024 - 09/2010
2	Insulin Resistance 08/2021 - 01/2014
2	Virus Diseases (Viral Diseases) 01/2021 - 10/2015
2	Inborn Genetic Diseases (Disease, Hereditary) 10/2019 - 11/2013
2	Glucose Intolerance 01/2019 - 01/2015
2	Dehydration (Water Stress) 01/2019 - 04/2016
2	Pancreatic Diseases (Pancreatic Disease) 01/2018 - 08/2008
2	Reperfusion Injury 03/2008 - 03/2003
2	Necrosis 01/2007 - 03/2003
2	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 11/2005 - 03/2002
1	Exocrine Pancreatic Insufficiency 04/2024
1	Ataxia Telangiectasia (Louis Bar Syndrome) 12/2023
1	Idiopathic Pulmonary Fibrosis 11/2023
1	Chronic Obstructive Pulmonary Disease (COPD) 11/2023
1	Pneumonia (Pneumonitis) 11/2023
1	Bronchiolitis Obliterans 01/2023
1	Chronic Disease (Chronic Diseases) 10/2022
1	B-Cell Lymphoma (Lymphoma, B Cell) 10/2022
1	Obstructive Lung Diseases (Obstructive Lung Disease) 01/2022
1	Pancreatitis 08/2021
1	Edema (Dropsy) 08/2021
1	Respiratory Tract Diseases (Respiratory Tract Disease) 01/2021

Drug/Important Bio-Agent (IBA)

21	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 11/2023 - 01/2002
9	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2016 - 11/2003
7	Proteins (Proteins, Gene)FDA Link 12/2023 - 03/2004
5	CytokinesIBA 11/2023 - 01/2007
5	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 01/2015
5	Chloride Channels (Chloride Channel)IBA 04/2016 - 08/2011
5	Reactive Oxygen Species (Oxygen Radicals)IBA 07/2013 - 03/2003
5	NF-kappa B (NF-kB)IBA 05/2008 - 01/2003
4	Insulin (Novolin)FDA Link 08/2021 - 01/2014
4	Viral DNAIBA 01/2021 - 01/2016
4	Messenger RNA (mRNA)IBA 01/2020 - 12/2002
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2009 - 12/2002
3	A-Form DNA (A-DNA)IBA 12/2023 - 01/2016
3	Phosphatidylinositols (Phosphatidylinositol)IBA 12/2023 - 01/2016
3	Phosphotransferases (Kinase)IBA 12/2023 - 01/2016
3	Small Interfering RNA (siRNA)IBA 12/2017 - 08/2006
3	ChloridesIBA 05/2016 - 09/2010
3	NF-KappaB Inhibitor alphaIBA 05/2008 - 12/2002
3	Superoxides (Superoxide)IBA 08/2006 - 04/2002
3	Proteasome Endopeptidase Complex (Proteasome)IBA 12/2004 - 03/2002
2	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA 12/2023 - 01/2017
2	DNA (Deoxyribonucleic Acid)IBA 12/2023 - 01/2017
2	RNA (Ribonucleic Acid)IBA 11/2023 - 12/2014
2	MucinsIBA 11/2023 - 01/2019
2	Amylases FDA Link 08/2021 - 01/2018
2	Complement System Proteins (Complement)IBA 01/2020 - 06/2015
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2018 - 03/2014
2	Antiviral Agents (Antivirals)IBA 01/2017 - 01/2016
2	Proteasome InhibitorsIBA 09/2013 - 07/2003
2	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 03/2008 - 03/2003
2	Oxidoreductases (Dehydrogenase)IBA 07/2007 - 09/2004
2	EndotoxinsIBA 01/2007 - 03/2004
2	DystrophinIBA 11/2005 - 03/2002
2	Doxorubicin (Adriamycin)FDA LinkGeneric 12/2004 - 03/2004
2	Superoxide DismutaseIBA 12/2004 - 04/2002
2	Transcription Factors (Transcription Factor)IBA 01/2003 - 12/2002
2	pervanadateIBA 01/2003 - 12/2002
2	Tyrosine (L-Tyrosine)FDA Link 01/2003 - 12/2002
1	ivacaftor drug combination lumacaftorIBA 04/2024
1	Histones (Histone)IBA 12/2023
1	DNA-Activated Protein KinaseIBA 12/2023
1	elexacaftorIBA 10/2023
1	ivacaftor drug combination tezacaftorIBA 10/2023
1	Small Cytoplasmic RNAIBA 01/2023
1	Peptides (Polypeptides)IBA 01/2023
1	mead acidIBA 12/2022
1	Linoleic Acid (Linoleate)IBA 12/2022
1	Fatty Acids (Saturated Fatty Acids)IBA 12/2022
1	Immunoglobulins (Immunoglobulin)IBA 10/2022
1	complement C4dIBA 10/2022
1	Hypoglycemic Agents (Hypoglycemics)IBA 08/2021
1	Interleukin-6 (Interleukin 6)IBA 08/2021
1	Lipase (Acid Lipase)FDA Link 08/2021
1	CeruletideIBA 08/2021
1	IncretinsIBA 01/2019
1	ivacaftorIBA 01/2019
1	acyl-ghrelinIBA 01/2019
1	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2019
1	Growth Hormone (Somatotropin)IBA 01/2019

Therapy/Procedure

18	Therapeutics 11/2023 - 12/2004
4	Lung Transplantation 11/2023 - 01/2018
1	Heterologous Transplantation (Xenotransplantation) 11/2023
1	Airway Management 09/2023